Journal: Biology
Article Title: Development of a Spinal Cord Injury Model Permissive to Study the Cardiovascular Effects of Rehabilitation Approaches Designed to Induce Neuroplasticity
doi: 10.3390/biology10101006
Figure Lengend Snippet: At 2 weeks post-SCI, animals underwent left ventricular catheterization to assess cardiac function. Pressure-volume analysis revealed reduced pressure, volume, and contractile function among SCI compared to naïve rats. ( A ) An example pressure-volume loop labelled with relevant indices acquired from pressure-volume analysis (ESV; end-systolic volume, EDV; end-diastolic volume, Pes; end-systolic pressure, Ped; end-diastolic pressure, SV; stroke volume, SW; stroke work (area of the pressure volume loop), ESPVR; end systolic pressure volume relationship, Ees slope of ESPVR). ( B ) Example basal pressure volume loop from SCI and naïve rats, overlaid with SEM bars, demonstrating diminished LV maximum pressure (22 ± 4 mmHg; p < 0.001) and EDV (50 ± 15 ul; p = 0.002) in SCI compared to naïve animals. C-D: Example inferior vena cava occlusions from naïve ( C ) and SCI ( D ) groups demonstrating reduced Ees among SCI compared to naïve animals (0.7 ± 0.1 mmHg/ul; p < 0.001).
Article Snippet: All PV indices were analyzed using the PV loop analysis software in Labchart8 (AD Instruments).
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